Valacyclovir

Valacyclovir is an FDA-approved generic prescription antiviral. Do not use with a known allergy to valacyclovir, acyclovir, or product excipients. Tell the provider about kidney disease, dehydration, older age, immune suppression, transplant history, TTP/HUS, pregnancy, breastfeeding, and every medication. Kidney-based dose adjustment is required when renal function is reduced. Maintain adequate hydration, especially during high-dose treatment. Common effects include headache, nausea, abdominal pain, dizziness, and fatigue. Acute kidney injury can occur, particularly with dehydration, excessive dosing, renal impairment, older age, or concurrent nephrotoxic drugs. Confusion, agitation, hallucinations, encephalopathy, tremor, and seizures can occur, especially with renal impairment or excessive exposure. Rare serious reactions include severe allergy and TTP/HUS, primarily reported in severely immunocompromised patients receiving high doses. Seek urgent care for markedly reduced urination, swelling, severe weakness, confusion, hallucinations, seizure, unusual bruising or bleeding, severe rash, facial swelling, or trouble breathing. Do not double missed doses or use another person's prescription. Valacyclovir does not cure HSV, does not eliminate asymptomatic shedding, and does not fully prevent transmission; combine suppressive therapy with provider-recommended safer-sex practices and avoid sexual contact during outbreaks. Store at 68–77°F, protect from moisture, and follow the pharmacy label BUD, which may be up to six months after dispensing without exceeding manufacturer expiration. Pregnancy and breastfeeding are not automatic exclusions, but require provider review.