Provider-Guided · Works In 5–20 Minutes
When Pills Aren't Enough
For the men the tablets left behind. Tri-Mix works through a different pathway — a physician-guided option when sildenafil and tadalafil stopped delivering.
- For men when oral ED pills haven't worked
- Typical onset in 5–20 minutes · results may vary
- Provider-guided dosing, titrated to fit you
- Everything ships in one discreet, cold-packed box
Analysis
Why Tri-Mix
When the tablets stop working, the pathway changes.
A different mechanism
Oral ED pills depend on your body’s own nitric-oxide signal. Tri-Mix works directly at the source — which is why it can help when pills don’t.
For non-responders
Formulated for men who’ve tried sildenafil or tadalafil without the result they were after. A real next step, not a higher dose of the same thing.
Dialed in with a provider
Your dose is titrated with a licensed provider so it’s calibrated to you — never one-size-fits-all.
The Formula
Three actives,
one direct approach.
Because Tri-Mix acts directly rather than relying on the nitric-oxide pathway that oral pills need, many men respond to it even after tablets have stopped working. Typical onset is 5–20 minutes. Individual results vary; use only as directed by your provider.
- Alprostadil — a prostaglandin that promotes direct vasodilation
- Papaverine — a smooth-muscle relaxant that supports sustained blood flow
- Phentolamine — helps maintain the response alongside the other two actives
What's included?
Board-Certified Clinicians
A U.S.-licensed provider reviews every order before it ships.
Provider-Guided Titration
Your dose is started low and adjusted to fit you — never one-size-fits-all.
Everything In One Box
Vial, sterile syringes, alcohol swabs, and a step-by-step quick-start guide with a video walkthrough.
Compounded & Lab-Tested
Compounded by a U.S.-licensed pharmacy; every batch is third-party tested for potency, sterility, pH, and endotoxicity.
Free Discreet Shipping
Shipped cold overnight in plain, unmarked packaging — no pharmacy name on the label.
Cancel Anytime
Pause, skip, or cancel from your patient portal in two clicks.
Simple, and closely supported
How it works
Start your free online visit — a short, private questionnaire about your history and what you’ve tried.
Start My Free Visit
A licensed provider reviews your visit, confirms it’s appropriate, and sets your starting dose.
Start My Free Visit
Compounded by our U.S. pharmacy, shipped cold and discreet — then titrated with you until it’s right.
Start My Free VisitI'd tried the tablets for years and had almost given up. This was the first thing that actually worked — and a real provider walked me through every step.— Verified MintRx patient · individual experience, results may vary
Start here
A free online visit. You only pay for medication.
● In Stock
30-day supply · 2.5mL Tri-Mix vial
- ✔Free Online Visit (Saving $40)
- ✔Free Online Prescription (Saving $20)
Includes $60 in free services (doctor visit + Rx).
Prescription required · Available to adults 18+ in the U.S.
Questions, answered
What is Tri-Mix?+
Tri-Mix is a compounded injectable medication combining three actives — alprostadil, papaverine, and phentolamine — used to manage erectile dysfunction, particularly in men who don't respond well to oral medications.
Why does it work when pills don't?+
Oral ED medications rely on your body's nitric-oxide pathway. Tri-Mix acts directly to promote blood flow, which is why many men respond to it even after tablets have stopped working. Individual results may vary.
How is it administered?+
Tri-Mix is a self-administered injection. Your provider determines your starting dose and gives clear instructions, and our pharmacists are available to answer questions. Onset is typically 5–20 minutes.
Is the dose customized?+
Yes. Dosing is titrated with your provider so it's calibrated to you specifically. You start conservatively and adjust under provider guidance until it's right.
What ships in my first order?+
Your first shipment includes the Tri-Mix vial, a phenylephrine reversal vial, sterile syringes, alcohol swabs, a product information insert with a QR code for video injection instructions, sharps-disposal information, and discreet packaging.
Does it require a prescription?+
Yes. Tri-Mix is a compounded medication requiring a prescription from a licensed provider. MintRx facilitates a telehealth consultation to determine whether it's appropriate for you.
Is it FDA-approved?+
Compounded medications are customized by a pharmacy for an individual patient and are not themselves FDA-approved. The active ingredients are sourced from FDA-registered facilities, and your prescription is filled by a licensed U.S. pharmacy.
You've tried the rest.
See if this is different.
Start your free online visit — a licensed provider reviews every visit and decides whether Tri-Mix is right for you, or whether an oral treatment is a better first step.
Under 5 minutes · No insurance needed · Cancel anytime
Important Safety Information
Tri-Mix is a compounded injectable medication. This medication is compounded by a state-licensed pharmacy. Compounded medications are not FDA-approved. The FDA does not verify the safety, effectiveness, or quality of compounded medications before they are marketed. This product is prepared in a U.S.-licensed pharmacy and undergoes third-party testing for potency, sterility, and quality.
Do not use Tri-Mix if you are allergic to any active ingredient, have been advised against sexual activity due to cardiovascular issues, or have a history of priapism. Do not combine with oral ED medications unless directed by your provider. Sterile technique is required — never share or reuse needles. Not for use in women or children. Priapism warning: if an erection lasts 4 or more hours, seek emergency care immediately.
Prescription medication is only available if prescribed after an online consultation with a healthcare provider. MintRx connects patients with licensed providers who may prescribe medication through state-licensed pharmacies. Individual results may vary, and no guarantees are provided. Read full safety information →