Estradiol Topical Cream

Estradiol Topical Cream

  • In Stock

Please note: We are temporarily unable to ship to the following states. AL, AR, DC, GA, ID, LA, ME, MD, MS, NV, NH, NC, OK, SC

How it works

Step 1. Have a Prescription

Upload a photo of your prescription after checkout. You can also text us a picture of your prescription or prescription label to 561-406-9485. We will call your doctor to confirm the prescription. Your physician can "escript"(send electronically)
Only choose "I have a prescription" if your doctor can validate and has prescribed this specific drug.

Step 2. Your Order Is Processed

Once we receive a prescription from your doctor, we will process your order. We only authorize your credit card at checkout and won't charge your card until we obtain a valid prescription.

Step 3. Your Medication Is Shipped

Your medication is on its way! We ship directly to your door. Never wait in a pharmacy line again!


Continuing your Estrogen Replacement Therapy (ERT) is easy when it is affordable and custom-made just for you. This compounded bioidentical estradiol cream is for topical use to supplement the body's levels of estrogen as the body approaches menopause and especially post-menopause. Topical application is absorbed by the body quickly and bypasses the digestive system enhancing the bioavailability of the estrogen. .4% estradiol delivered in a 30 gram pump. We cannot offer this medication in Iowa

Compounded products are made specific to each order and will ship between 24-48 business hours. Upon approval of a cancellation or refund request, only the Rx product, not the consultation fee, will be refunded.


Made Just For You - Bioidentical Topical Estrogen Cream

Transdermal estradiol cream is an alternative to vaginal application. It is indicated for the treatment of menopause symptoms or to restore hormonal balance in women who may have other health conditions.

It works by replacing estrogen that the body becomes less capable of creating as women age. Noticeable decline usually begins during perimenopause, 8-10 years before menopause. The average age of ;menopause in the US is 51.

Postmenopause, estrogen production continues to decrease. Low estrogen in women is commonly associated with hot flashes, depression, brain fog, sexual dysfunction, vaginal dryness, and osteoporosis.

This custom-compounded cream is bioidentical to natural estradiol made in the body. It is made for topical application to the skin (transdermal).

What Is Bioidentical Estradiol? 

All bioidentical hormones are molecular and structural matches to hormones made by the body. They are synthesized in a lab from diosgenin, a natural substance found in wild yams and soy.

Estradiol is the strongest of the three sex hormones called estrogens made in the body. The other two estrogens are estrone and estriol. Estrogens are responsible for female secondary sex characteristics, as well as the health and function of the female reproductive system.

Transdermal Estrogen vs Vaginal

Vaginal and topical estrogen creams bypass the digestive system which helps ensure that more of the active ingredient is available for use by the body. Topical and vaginal application work faster than oral estrogen. Their direct absorption into the body has been shown to have less impact on the body's other organs.

Vaginal application of estradiol is ideal for treating vaginal dryness, thinning of the vaginal walls and pain during sex that often develop due to reduced estrogen.

Topical estradiol is absorbed through the skin and impacts systemic levels of estrogen but not to the degree of oral estrogen. It is typically available in higher dose formulas than vaginal estrogen cream. Topical estrogen creams are usually applied to the thighs and calves.

Estrogen Oral vs Estrogen Patches

ERT can also be administered orally. Even though oral estrogen passes through the digestive system where it loses some potency, it circulates through the entire body. It has a systemic effect, while vaginal or topical delivery are targeted.

Transdermal patches are the most direct and potent delivery form other than injection or sublingual administration.

Troches are a method of sublingual delivery. Troches are lozenges that dissolve beneath the tongue and directly absorbed into the bloodstream.

Learn about your options for custom bHRT through MintRx!

This product is made by a MintRx partner, a 3rd party licensed, sterile compounding pharmacy.

These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.

This compounded product contains a total of 30g of custom blended .4% bioidentical estradiol. It is delivered in a pump with auto measuring. The potency is 4mg per gram.

How to Use

Apply estradiol cream to both thighs and calves (lower legs). Apply to skin that is clean, completely dry and not red, irritated, or broken. Do not apply to your breasts.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If you forget a dose of estradiol cream but remember more than 12 hours before you are scheduled to apply your next dose, apply the missed dose right away. If you remember less than 12 hours before you are scheduled to apply your next dose, skip the missed dose and continue your regular dosing schedule the next day.

Do not apply extra estradiol cream to make up for a missed dose.

Tell your doctor if any of these symptoms are severe or do not go away:

  • Headache breast pain or tenderness
  • Nausea
  • Diarrhea
  • Constipation
  • Gas
  • Heartburn
  • Weight gain or loss
  • Mood changes
  • Depression or nervousness
  • Sleepiness
  • Difficulty falling asleep or staying asleep
  • Changes in sexual desire
  • Back pain
  • Runny nose
  • Cough or flu-like symptoms
  • Hair loss
  • Unwanted hair growth
  • Darkening of the skin on the face
  • Difficulty wearing contact lenses
  • Irritation or redness of the skin at the application area
  • Swelling
  • Redness
  • Burning
  • Irritation, or itching of the vagina vaginal discharge

These products are made by a MintRx partner, a 3rd party licensed, sterile compounding pharmacy.

This Product Is FSA/HSA Eligible

Score! You may purchase this product by simply using your FSA/HSA debit card at checkout.

How Do I Use My FSA/HSA Debit Card At MintRx?

  • Place all of your qualifying items in your cart. All MintRx prescriptions, including our custom-made medications, are approved for FSA and HSA purchase. Also, use your FSA/HSA debit for qualified over-the-counter items such as at-home lab tests and acne treatments. We've marked each FSA/HSA eligible item with a badge.
  • Make your purchase using your debit card.

What If I Want To Purchase Items That Are Not FSA/HSA Approved?

If you are also buying non-eligible FSA/HSA items, you are required to make a separate transaction.

What Are FSA and HSA Accounts?

FSA's and HSA's are federal programs that make it easy for you to enjoy significant tax benefits for qualified out-of-pocket medical expenses. Each program works a little differently but with each you avoid federal, state and local income taxes on any funds that you use for qualified medical expenses.

FSA tax benefits are administered by your job. Funds in an amount that you decide —within the program limits—are withdrawn from your paycheck without any payroll tax deductions.

Tax benefits with an HSA may be administered that way but there are also other options.

How Do I Use My FSA/HSA Funds?

You can use a pre-loaded debit card or get reimbursed from your FSA or HSA account after you make your purchase or a combination of both methods.